Notebook titled 'NULS / May 1955'
- Reference:GB 237 Coll-1255/5/16
- Dates of Creation:May 1955 - September 1960
- Language of Material:English
- Physical Description:1 notebook 1 folder20.5 x 26cm 1 notebook , 1 folder20.5 x 26cm
Scope and Content
Notebook contains notes relating to the 'nuls' resulting from Beale's work on intragenic recombination.
The notebook has been written in from both ends. There are also some loose leaf notes which were inserted into the volume.
Administrative / Biographical History
These notes relate to Beale's work on intragenic recombination among the antigen-determining genes in Paramecium. Beale constructed heterozygotes involving various combinations of different 'd' antigen alleles, passed them through autogamy and screened the progeny with sera capable of immobilising the parental types. Theoretically intragenic recombinants should have appeared, but the only novel types Beale got turned out to be 'nuls' - i.e. cells unable to express any antigen controlled by the locus corresponding to the original types used.
Subjects